Osteogenesis imperfecta and intravenous pamidronate
نویسندگان
چکیده
منابع مشابه
Cyclical intravenous pamidronate therapy in children with osteogenesis imperfecta.
137 Children affected with osteogenesis imperfecta (OI) have increased morbidity and mortality and no definite treatment has been found yet. Recurrent fractures and bone deformities are the main complications of this disease. Recent studies have shown the ability of intravenous pamidronate to prevent fractures, when given in a cyclical manner [1]. This treatment is being used currently to preve...
متن کاملEffect of intravenous pamidronate treatment in children with osteogenesis imperfecta.
OBJECTIVE To assess the beneficial effect of intravenous pamidronate treatment in children with osteogenesis imperfecta (OI). STUDY DESIGN Experimental study. PLACE AND DURATION OF STUDY Endocrine Unit at the National Institute of Child Health, Karachi, Pakistan, from January 2007 to December 2011. METHODOLOGY All children diagnosed with osteogenesis imperfecta on the basis of repeated sp...
متن کاملBenefits of Pamidronate Treatment in Osteogenesis Imperfecta
Received March 9, 2004 Abstract Osteogenesis imperfecta is a hereditary disorder of connective tissues characterised by low bone mass and bone fragility. Previous studies demonstrated that cyclical pamidronate therapy is effective in increasing bone density and improving clinical outcomes in children with osteogenesis imperfecta. We report our experience in treating two children with cyclical i...
متن کاملHypercalcaemia in osteogenesis imperfecta treated with pamidronate.
The response to the bisphosphonate, pamidronate, is reported in a child with osteogenesis imperfecta who had recurrent symptomatic hypercalcaemia after immobilisation following fractures. Oral clodronate was effective in the prevention of immobilisation hypercalcaemia in the same child. The bisphosphonates may have other roles in osteogenesis imperfecta by decreasing bone turnover.
متن کاملVertebral morphometry in children and adolescents with osteogenesis imperfecta: effect of intravenous pamidronate treatment.
Results in small patient series suggest that cyclical intravenous treatment with pamidronate can lead to reshaping of compressed vertebral bodies in children and adolescents with osteogenesis imperfecta (OI), but more detailed analyses are lacking. In this study of patients with moderate to severe OI (age range 0.1 to 16.7 years), we used vertebral morphometry to longitudinally assess changes i...
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ژورنال
عنوان ژورنال: Archives of Disease in Childhood
سال: 2002
ISSN: 0003-9888,1468-2044
DOI: 10.1136/adc.87.6.562-a